Figure 2.

Influence of islet size (expressed as islet size index of the preparation) on insulin secretion by isolated human islets. (A) Dynamics of insulin secretion in islet preparations with a size index lower or higher than 1.0. Values are means ± SE for 21 and 22 islet preparations. Significant differences between the two groups during reference periods are denoted by *(P < 0.05) (Mann–Whitney test). (B–D) Basal insulin secretion rate in G1 (B), whole insulin response to G15 (C) and normalized islet insulin content (D), as a function of the islet size index. Correlation coefficients were calculated by the test of Spearman. (C) The inset compares stimulation index (SI) for whole insulin responses to G15 (means ± SE) in islet preparations with an islet size index below or above 1.