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. 2018 Mar 13;6(5):e13646. doi: 10.14814/phy2.13646

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© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Influence of donor age on insulin secretion by isolated human islets. (A) Islet size index. (B) Normalized islet insulin content. (C) Dynamics of insulin secretion. (D–E) Stimulation index (SI) for the first phase and the whole response to G15. Values are means ± SE for 23 islet preparations from donors aged ≤48 years and 20 preparations from donors aged >48 years. All comparisons by Mann–Whitney test. (F–G) First phase insulin response to G15 (F) and whole insulin response to tolbutamide (G) as a function of donor age. Correlation coefficients were calculated by the test of Spearman.