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In vitro microsomal stabilities of compounds 10f, 10h, 10k and 10n.
| compound | Mouse | Rat | Human | |||
|---|---|---|---|---|---|---|
|
|
|
|
||||
| t1/2 (h) | Clint(ml/min/kg) | t1/2 (h) | Clint(ml/min/kg) | t1/2 (h) | Clint(ml/min/kg) | |
|
|
|
|
||||
| 10f | 1.36±0.06 | 42.1 | 1.29±0.03 | 36.1 | 4.59±0.39 | 4.5 |
|
| ||||||
| 10h | 1.17±0.06 | 48.7 | 1.20±0.05 | 39.0 | 2.16±0.19 | 9.6 |
|
| ||||||
| 10k | 1.20±0.07 | 47.8 | 1.62±0.10 | 29.0 | 3.50±0.36 | 5.9 |
|
| ||||||
| 10n | 0.88±0.06 | 65.1 | 1.26±0.06 | 37.0 | 2.80±0.18 | 7.4 |
