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. 2018 Mar 13;6(5):e13643. doi: 10.14814/phy2.13643

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© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Ablation of SOCS3 in LepR cells leads to metabolic alterations in gestation. (A–B) Bar graphs comparing the increase in body weight (n = 17–19/group) and food intake (n = 9–17/group) during pregnancy in control and SOCS3 KO mice. (C) Bar graph comparing gestation time (days) in control (n = 24) and SOCS3 KO mice (n = 23). (D) Number of embryos and uterine reabsorptions of late pregnant control (n = 12) and SOCS3 KO (n = 12) mice. *Significantly different (P < 0.05) compared to control group.