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. 2018 Mar 13;4:6. doi: 10.1038/s41526-018-0040-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Heart rate elevations during missions correlated with the rate of body mass loss. Both variables are shown as a percentage: (pre-flight–post-flight) divided by pre-flight. Linear regression of flight data (dashed line) had a correlation coefficient of 0.72; note that simulation data, although few in number, also appear to fit this correlation