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. 2017 Dec 22;74(4):455–464. doi: 10.1007/s00228-017-2404-2

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Comparison of [¹⁴C]siponimod metabolism rates in human liver microsomes (HLM) from individual donors with three different CYP2C9 genotypes. Formation of total metabolites was quantified by HPLC with radioactivity detection. Student’s t tests are applied for comparing the significant difference of CYP2C9*1/*1 to CYP2C9*2/*2 (p value 0.0477) and CYP2C9*1/*1 to CYP2C9*3/*3 (p value 0.0424), respectively. CYP cytochrome P450