Table 1.
Histopathological types of NF-PitNETs with diagnostic and potential prognostic/predictive immunohistochemical markers
| NF-PitNET type | Transcriptional factor | Hormone staining | LMWCK | Prognostic/predictive markers |
|---|---|---|---|---|
| Gonadotroph | SF-1 (GATA-2, ERα) | β-FSH, β-LH, α-SU | Variable | ERα, SSTRs |
| Corticotropha | T-Pit | ACTH | Diffuse | |
| Type 1 (densely granulated) | T-Pit | Diffuse, strong ACTH | Diffuse | |
| Type 2 (sparsely granulated) | T-Pit | Weak, patchy ACTH | Diffuse | |
| Crooke-cell | T-Pit | Periphery of the cell | Ring-like | |
| Somatotroph | Pit-1 | GH | SSTRs | |
| Sparsely granulateda | Pit-1 | Diffuse, strong | Fibrous body | |
| Densely granulated | Pit-1 | Weak, patchy | Diffuse | |
| Thyrotroph | Pit-1 (GATA-2) | TSH, α-SU | Variable | SSTRs |
| Lactotroph | Pit-1 (ERα) | PRL | Variable | |
| Sparsely granulated | Pit-1 (ERα) | Perinuclear, Golgi zone PRL | Variable | |
| Densely granulated | Pit-1 (ERα) | Diffuse PRL | Variable | |
| Acidophilic stem cell adenoma | Pit-1 (ERα) | Focal and variable PRL, GH | Fibrous body (inconsistent) | |
| Plurihormonal Pit-1a | Pit-1 | GH, PRL, TSH, α-SU | Variable | |
| Null-cell | None | None | Variable | |
| Double/triple NF-PitNET | More than one | Variable | Variable |
Increased proliferation and MRI-confirmed invasion are criteria for high-risk adenoma in all types. MGMT is a potential predictive marker for response to temozolomide in aggressive PitNETs of all types
aNF-PitNET types with potential aggressive biological behavior