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Demethylation of the investigated thiosemicarbazones detected via LC-HRMS after cell-free incubations with HLM with the intensities of the obtained metabolites (✓: > 106 AU, ~: 105–106 AU, x: < 104 AU; the gray areas represent metabolic reactions which are not possible)
*The demethylated/dehydrogenated metabolite is not a product of the simply demethylated metabolite
