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. 2018 Mar 13;8:4403. doi: 10.1038/s41598-018-22553-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Rescue of cochlear remodeling by T3 treatment. (A) Scheme of administration of T3 (or saline vehicle) by sc injections at P0-P2 then analysis at P5. (B) Histological sections of the mid-lower cochlea showing status of remodeling. T3 but not saline stimulates opening of the inner sulcus (is) and tunnel of Corti (tc), regression of the greater epithelial ridge (ger) and a thinner tectorial membrane (tm, grey arrow) in both dko and wt mice. (C) Measurements of open areas of the inner sulcus (IS) and tunnel of Corti (TC) after treatment with saline or T3 given at 0.2 or 1.5 μg/day. Measured on middle regions of the cochlea on plastic sections using ImageJ. Groups were compared to saline-treated wt mice following a two-way ANOVA; *p = 0.0105; ***p < 0.001.