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. 2018 Mar 13;8:4403. doi: 10.1038/s41598-018-22553-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Auditory responses in dko mice after T3 treatment. (A) ABR mean thresholds at P28 after treatment with T3 in drinking water from P7 to P28. Groups contained 5 wt and 6 dko. Comparisons were made within genotype by two-way ANOVA; ***p < 0.001. (B) Scheme for treatment with T3. (C) Enhanced definition and amplitudes of ABR peaks in T3-treated mice; representative traces for a click stimulus. Note different scale bars (μV) for wt and dko. (D) Waveform amplitudes (mean ± sem) in wt and dko mice. Amplitudes were determined for peak 1 to the following trough for a click and representative pure tone (16 kHz) stimulus. T3 made little difference in wt mice (p > 0.3) but enhanced amplitudes in dko mice for 16 kHz (**p = 0.0022) and a click (but not statistically significant, p = 0.5602). Groups of 3 untreated and 5 treated wt; 5 untreated and 6 treated dko. (E) Endocochlear potential in dko mice was not restored by treatment with T3. The endocochlear potential was significantly reduced in untreated dko (**p = 0.01) and T3 treated dko (***p < 0.001) compared to wt untreated mice at this age, similar to the defect in adult mice.