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. 2018 Mar 13;8:4459. doi: 10.1038/s41598-018-22222-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Prevalence of IDH^105GGT. (A) Comparison of IDH^105GGT between controls and patients with brain tumors. (B) IDH^105GGT in grade II, III and IV brain tumors. (C) IDH^105GGTin gliomas with and without IDH tumor missense mutation. (D) IDH^105GGT in grade II and III gliomas with and without IDH tumor missense mutation and in grade IV without IDH tumor missense mutation. IDH^105GGT: cases with IDH^105GGT; No-IDH^105GGT: cases without the IDH^105GGT; GII: grade II brain tumors; GIII: grade III brain tumors; GIV: grade IV brain tumors; GBM: glioblastoma; R132: cases with IDH-missense mutation; WT: wild type.