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. 2018 Mar 13;8:4407. doi: 10.1038/s41598-018-22729-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional C-terminally truncated SNAP-mGlu₅ receptor dimer. (A) 3-Dimensional model of the human mGlu₅ receptor truncated after residue Ala856. The truncated receptor is composed of all segments required for effective G protein signaling, including the Venus Flytrap domain (VFT), Cysteine-Rich Domain (CRD) and the heptahelical transmembrane domain (7TM). The red and green spheres represent the orthosteric and allosteric binding sites, respectively. (B) Glutamate- and quisqualate-induced IP1 production in HEK293 cells transiently transfected with SNAP-Tag full-length human mGlu₅ receptor (black and grey curves) or SNAP-Tag C-terminal mGlu₅-Δ856 receptor (red and orange curves), respectively. (C) Thermal stability of the full-length wild-type mGlu₅ and mGlu₅-Δ856 [³H]-MPEP-bound receptors. Data points for both assays represent the mean ± SEM of three independent experiments.