Table 3.

Plk2 gene mutations occur infrequently in colorectal cancer

Patient	Organ Site	Variation Type	cDNA	Protein	p53-Mutation
I	Colon	Missense Mutation	c.A1699G	p.S567G
II	Rectal	Nonsense Mutation	c.C2014T	p.R672*
		Missense Mutation	c.C1336T	p.R446W
		Missense Mutation	c.C1089A	p.F363L
III	Colon	Nonsense Mutation	c.1171G>T	p.E391*
IV	Colon	Missense Mutation	c.274G>T	p.G92C	p.D186G;p.R1 75H;p.S95P
V	Colon	Missense Mutation	c.346A>C	p.S116R	p.I255T;p.V218A
	Colon	Missense Mutation	c.274G>T	p.G92C
VI	Colon	Missense Mutation	c.274G>T	p.G92C
VII	Colon	Silent	c.276C>T	p.G92G	p.R1 75H
VIII	Colon	Frame Shift Insertion	c.1004_1005insT	p.L335fs
IX	Colon	Frame Shift Deletion	c.1005delG	p.L335fs	p.P3 01fs
X	Colon	Missense Mutation	c.G1856T	p.G619V	p.R273C
XI	Rectal	Missense Mutation	c.C1089A	p.F363L
XII	Colon	Frame Shift Deletion	c.1004delT	p.L335fs
XIII	Colon	Frame Shift Deletion	c.1004delT	p.L335fs

Total Number of Colorectal Cancer Patients = 494 cases The Plk2 gene is on chromosome 5.

Patients I t o III I are common to Broad Firehose an d TCGA.

Patients IX to XIII are not in Broad Firehose but present in TCGA.

Five patients unique to Broad Firehose.