Table 1.
miRNA | SNP | Allele |
Case (n = 393) |
Control (n = 812) |
Heterozygous (AB versus AA) |
Dominant (AB/BB versus AA) |
Recessive (BB versus AB/AA) |
HWE | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A | B | AA | AB | BB | AA | AB | BB | AOR (95% CI)a | p Valuea | AOR (95% CI)a | p Valuea | AOR (95% CI)a | p Valuea | |||
miR-27a | rs895819 | T | C | 220 | 153 | 20 | 442 | 312 | 58 | 0.99 (0.77–1.27) | 0.913 | 0.94 (0.74–1.20) | 0.623 | 0.70 (0.42–1.18) | 0.184 | 0.772 |
miR-34b/c | rs4938723 | T | C | 221 | 107 | 49 | 377 | 358 | 75 | 0.51 (0.39–0.67)b | <0.0001b | 0.62 (0.48–0.79)b | 0.0001b | 1.46 (1.00–2.15) | 0.052 | 0.448 |
miR-137 | rs1625579 | T | G | 343 | 46 | 3 | 719 | 90 | 1 | 1.07 (0.74–1.57) | 0.717 | 1.13 (0.78–1.64) | 0.519 | 6.23 (0.65–60.00) | 0.114 | 0.290 |
miR-146a | rs2910164 | C | G | 142 | 189 | 60 | 282 | 397 | 130 | 0.94 (0.72–1.23) | 0.671 | 0.94 (0.73–1.20) | 0.607 | 0.94 (0.68–1.32) | 0.728 | 0.621 |
miR-149 | rs2292832 | T | C | 286 | 62 | 32 | 560 | 172 | 59 | 0.70 (0.51–0.97)b | 0.032b | 0.79 (0.60–1.05) | 0.106 | 1.14 (0.73–1.79) | 0.559 | <0.001 |
miR-196a2 | rs11614913 | T | C | 107 | 192 | 94 | 230 | 399 | 183 | 1.04 (0.78–1.39) | 0.793 | 1.06 (0.81–1.39) | 0.673 | 1.08 (0.81–1.43) | 0.607 | 0.691 |
miR-218 | rs11134527 | A | G | 154 | 164 | 73 | 276 | 403 | 131 | 0.73 (0.56–0.96)b | 0.022b | 0.80 (0.62–1.02) | 0.073 | 1.19 (0.86–1.63) | 0.290 | 0.425 |
miR-423 | rs6505162 | C | A | 244 | 132 | 17 | 522 | 258 | 31 | 1.09 (0.84–1.42) | 0.497 | 1.10 (0.86–1.41) | 0.448 | 1.13 (0.62–2.07) | 0.694 | 0.900 |
miR-608 | rs4919510 | G | C | 127 | 190 | 76 | 227 | 405 | 179 | 0.84 (0.64–1.11) | 0.217 | 0.81 (0.63–1.06) | 0.122 | 0.84 (0.62–1.14) | 0.263 | 0.948 |
AOR, adjusted odds ratio; CI, confidence interval; HWE, Hardy-Weinberg equilibrium.
Adjusted for age and gender.
For these values, the 95% CI excluded 1 or p < 0.05.