. 2018 Jan 31;11:1–8. doi: 10.1016/j.omtn.2018.01.003

Table 2.

Stratified Analyses on Associations of rs4938723 T > C and rs11134527 A > G Polymorphisms with Neuroblastoma Risk

Variables	rs4938723 (Cases/Controls)		Crude OR (95% CI)	p Value	Adjusted OR (95% CI)^a	p Value^a	rs11134527 (Cases/Controls)		Crude OR (95% CI)	p Value	Adjusted OR (95% CI)^a	p Value^a
Variables	TT	TC/CC	Crude OR (95% CI)	p Value	Adjusted OR (95% CI)^a	p Value^a	AA	AG/GG	Crude OR (95% CI)	p Value	Adjusted OR (95% CI)^a	p Value^a
Age (months)
≤18	75/146	45/159	0.55 (0.36–0.85)^b	0.007^b	0.55 (0.36–0.85)^b	0.007^b	52/107	74/198	0.77 (0.50–1.18)	0.226	0.77 (0.50–1.18)	0.227
>18	146/231	111/274	0.64 (0.47–0.87)^b	0.004^b	0.64 (0.47–0.87)^b	0.004^b	102/169	163/336	0.80 (0.59–1.10)	0.166	0.81 (0.59–1.10)	0.168
Gender
Females	103/160	60/181	0.52 (0.35–0.76)^b	0.007^b	0.52 (0.35–0.76)^b	0.007^b	63/123	103/218	0.92 (0.63–1.35)	0.680	0.92 (0.63–1.36)	0.687
Males	118/217	96/252	0.70 (0.51–0.97)^b	0.032^b	0.70 (0.51–0.97)^b	0.031^b	91/153	134/316	0.71 (0.51–0.99)^b	0.044^b	0.72 (0.52–0.995)^b	0.046^b
Sites of Origin
Adrenal gland	101/377	51/433	0.44 (0.31–0.63)^b	<0.0001^b	0.44 (0.31–0.64)^b	<0.0001^b	59/276	94/534	0.82 (0.58–1.18)	0.286	0.83 (0.58–1.19)	0.312
Retroperitoneal	35/377	42/433	1.05 (0.65–1.67)	0.855	1.05 (0.65–1.68)	0.849	32/276	54/534	0.87 (0.55–1.38)	0.561	0.86 (0.54–1.37)	0.530
Mediastinum	60/377	46/433	0.67 (0.44–1.00)	0.052	0.67 (0.45–1.02)	0.059	47/276	61/534	0.67 (0.45–1.01)	0.055	0.68 (0.45–1.02)	0.059
Other	21/377	14/433	0.58 (0.29–1.16)	0.122	0.58 (0.29–1.16)	0.121	14/276	22/534	0.81 (0.41–1.61)	0.552	0.81 (0.41–1.61)	0.547
Clinical Stages^c
I + II + 4 s	92/377	66/433	0.63 (0.44–0.88)^b	0.008^b	0.63 (0.44–0.89)^b	0.008^b	65/276	97/534	0.77 (0.55–1.09)	0.141	0.78 (0.55–1.10)	0.151
III + IV	119/377	83/433	0.61 (0.44–0.83)^b	0.002^b	0.60 (0.44–0.83)^b	0.002^b	82/276	127/534	0.80 (0.59–1.10)	0.164	0.80 (0.59–1.10)	0.174

OR, odds ratio; CI, confidence interval; INSS, International Neuroblastoma Staging System.

Adjusted for age and gender, omitting the corresponding stratification factor.

For these values, the 95% CI excluded 1 or p < 0.05.

INSS criteria defined stage 4 s as age <1 year old, with localized primary tumor as delineated in stage I or II, and with dissemination limited to liver, skin, or bone marrow.