Table 2.
Variables | rs4938723 (Cases/Controls) |
Crude OR (95% CI) | p Value | Adjusted OR (95% CI)a | p Valuea | rs11134527 (Cases/Controls) |
Crude OR (95% CI) | p Value | Adjusted OR (95% CI)a | p Valuea | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|
TT | TC/CC | AA | AG/GG | |||||||||
Age (months) | ||||||||||||
≤18 | 75/146 | 45/159 | 0.55 (0.36–0.85)b | 0.007b | 0.55 (0.36–0.85)b | 0.007b | 52/107 | 74/198 | 0.77 (0.50–1.18) | 0.226 | 0.77 (0.50–1.18) | 0.227 |
>18 | 146/231 | 111/274 | 0.64 (0.47–0.87)b | 0.004b | 0.64 (0.47–0.87)b | 0.004b | 102/169 | 163/336 | 0.80 (0.59–1.10) | 0.166 | 0.81 (0.59–1.10) | 0.168 |
Gender | ||||||||||||
Females | 103/160 | 60/181 | 0.52 (0.35–0.76)b | 0.007b | 0.52 (0.35–0.76)b | 0.007b | 63/123 | 103/218 | 0.92 (0.63–1.35) | 0.680 | 0.92 (0.63–1.36) | 0.687 |
Males | 118/217 | 96/252 | 0.70 (0.51–0.97)b | 0.032b | 0.70 (0.51–0.97)b | 0.031b | 91/153 | 134/316 | 0.71 (0.51–0.99)b | 0.044b | 0.72 (0.52–0.995)b | 0.046b |
Sites of Origin | ||||||||||||
Adrenal gland | 101/377 | 51/433 | 0.44 (0.31–0.63)b | <0.0001b | 0.44 (0.31–0.64)b | <0.0001b | 59/276 | 94/534 | 0.82 (0.58–1.18) | 0.286 | 0.83 (0.58–1.19) | 0.312 |
Retroperitoneal | 35/377 | 42/433 | 1.05 (0.65–1.67) | 0.855 | 1.05 (0.65–1.68) | 0.849 | 32/276 | 54/534 | 0.87 (0.55–1.38) | 0.561 | 0.86 (0.54–1.37) | 0.530 |
Mediastinum | 60/377 | 46/433 | 0.67 (0.44–1.00) | 0.052 | 0.67 (0.45–1.02) | 0.059 | 47/276 | 61/534 | 0.67 (0.45–1.01) | 0.055 | 0.68 (0.45–1.02) | 0.059 |
Other | 21/377 | 14/433 | 0.58 (0.29–1.16) | 0.122 | 0.58 (0.29–1.16) | 0.121 | 14/276 | 22/534 | 0.81 (0.41–1.61) | 0.552 | 0.81 (0.41–1.61) | 0.547 |
Clinical Stagesc | ||||||||||||
I + II + 4 s | 92/377 | 66/433 | 0.63 (0.44–0.88)b | 0.008b | 0.63 (0.44–0.89)b | 0.008b | 65/276 | 97/534 | 0.77 (0.55–1.09) | 0.141 | 0.78 (0.55–1.10) | 0.151 |
III + IV | 119/377 | 83/433 | 0.61 (0.44–0.83)b | 0.002b | 0.60 (0.44–0.83)b | 0.002b | 82/276 | 127/534 | 0.80 (0.59–1.10) | 0.164 | 0.80 (0.59–1.10) | 0.174 |
OR, odds ratio; CI, confidence interval; INSS, International Neuroblastoma Staging System.
Adjusted for age and gender, omitting the corresponding stratification factor.
For these values, the 95% CI excluded 1 or p < 0.05.
INSS criteria defined stage 4 s as age <1 year old, with localized primary tumor as delineated in stage I or II, and with dissemination limited to liver, skin, or bone marrow.