Table 1.
The main pharmacokinetic parameters of agomelatine in two group (n=5)
| Parameters | Group A | Group B |
|---|---|---|
| AUC(0–t) (µg·h·L−1) | 911.24±568.38 | 1,946.20±459.48* |
| AUC(0–∞) (µg·h·L−1) | 1,773.16±1,390.90 | 2,782.93±1,947.76 |
| t1/2 z (h) | 23.98±35.22 | 29.71±9.78 |
| Tmax (h) | 0.45±0.11 | 0.40±0.14 |
| CLz/F (L·h−1·kg−1) | 18.05±13.14 | 9.35±4.28 |
| Cmax (µg·L−1) | 715.99±496.38 | 1,603.14±348.56* |
Notes: Group A, control group; Group B, a single dose of 30 mg/kg celecoxib.
*
P<0.05 in comparison to Group A.
Abbreviations: AUC, area under the concentration-time curve; CLz, clearance; Cmax, maximum concentration; t1/2z, terminal elimination half-life; Tmax, time to reach Cmax.