Table 2.

Factors Associated With Increased White Blood Cell Count

	Unadjusted Models		Adjusted Model
Predictor	Estimate (95% CI)	P Value	Estimate (95% CI)	P Value
Heavy marijuana usea	1.09 (1.01, 1.18)	.023	1.10 (1.02, 1.19)	.012
Moderate/heavy cigarette smokingb	1.12 (1.05, 1.19)	<.0001	1.15 (1.08, 1.22)	<.0001
Age 45–60 vs 40–44	1.05 (0.98, 1.13)	.152	1.05 (0.98, 1.13)	.172
Race
White	1.00 (Ref.)	—	1.00 (Ref.)	—
Black	0.86 (0.80, 0.92)	<.0001	0.87 (0.81, 0.94)	<.001
Other	0.96 (0.88, 1.05)	.331	0.97 (0.89, 1.05)	.425
Diabetes risk factorc	1.03 (0.91, 1.16)	.677	—	—
Hypertension risk factord	1.04 (0.98, 1.11)	.179	—	—
Total cholesterol (mg/dL)
<180	1.00 (Ref.)	—	1.00 (Ref.)	—
180–229	1.13 (1.06, 1.21)	<.001	1.11 (1.04, 1.18)	.002
≥230	1.11 (1.01, 1.21)	.023	1.10 (1.01, 1.20)	.022
HIV viral load ≥400 copies/mL	0.88 (0.82, 0.96)	.002	0.90 (0.83, 0.97)	.006

Models were fit using linear regression with time-updated log₂-transformed white blood cell count (cells/µL) as the dependent variable, from the merged HIV+ cohort at first incident cardiovascular event after age 40, loss to follow-up, last visit in 2010, or age 60. All laboratory test values were the mean of the 2 most recent visits prior to endpoint.

Abbreviations: CI, confidence interval; HIV, human immunodeficiency virus.

^aDaily or weekly marijuana use at ≥50% of visits in period 10 years prior to endpoint.

^bAverage ≥0.25 packs/day in period 10 years prior to endpoint.

^cHemoglobin A1C ≥6.5% or use of diabetes medications for at least 1 year in the 10 years prior to endpoint.

^dSystolic blood pressure >140 or diastolic blood pressure >90, or use of antihypertensive medications for at least 1 year in the 10 years prior to endpoint.