Table 1.
Clinical Characteristics of 12 Patients With Prosthetic Joint Infection Caused by Propionibacterium avidum, Either as a Monomicrobial (n = 8) or Part of a Polymicrobial (n = 4) Infection, at the Time of Initial Surgical Treatment of Infection at the University Hospital Balgrist
| Characteristic | No. (%) |
|---|---|
| Age, y, median (range) | 61 (45–81) |
| Female sex | 7 (58.3) |
| BMI, kg/m2, median (range) | 34.0 (27.9–40.6) |
| Obesity grade 1 (>30–<35) | 3 (25) |
| Obesity grade 2 (>35–<40) | 5 (41.7) |
| Obesity grade 3 (>40) | 1 (8.3) |
| Underlying joint disorder for arthroplasty | |
| Degenerative | 9 (75) |
| Trauma | 2 (16.7) |
| “Head necrosis” | 1 (8.3) |
| Place of last arthroplasty surgery before infection | |
| University Hospital of Balgrist | 7 (58.3) |
| Other hospital | 5 (41.7) |
| Localization of infection | 12 |
| Hip PJI | 10 (83.3) |
| Shoulder PJI | 2 (16.7) |
| Signs and symptoms | |
| Pain | 12 (100) |
| Wound secretion or sinus tract | 6 (50) |
| Swelling, skin erythema | 4 (33.3) |
| Fever | 4 (33.3) |
| Time to diagnosis of infection after last surgical revision of arthroplastya | |
| Median (range), wk | 13.1 (2.3–63.2) |
| Time to initial septic surgery after last surgical revision of arthroplasty | |
| Median (range), wk | 30.2 (2.9–100.3) |
| Surgical treatment | |
| DAIR including partial exchange of prosthesis | 5 (41.6) |
| 1-stage exchange | 2 (16.7) |
| 2-stage exchange | 4 (33.3) |
| Antibiotic treatment only | 1 (8.3) |
| Per oral antibiotic treatment after initial IV treatment | |
| Clindamycin | 4 (33.3) |
| Levofloxacin/rifampin | 4 (33.3) |
| Ciprofloxacin/rifampin | 2 (16.7) |
| Clindamycin/rifampin | 2 (16.7) |
Abbreviations: BMI, body mass index; DAIR, debridement-antibiotics-irrigation-retention; IV, intravenous; PJI, prosthetic joint infection.
aTime to first microbiological diagnosis of P. avidum (either preoperative synovial puncture or intraoperative tissue samples) with confirmation of infection due to Musculoskeletal Infection Society criteria [13].