Table 2.
B-Cell/T-Cell Receptor Motifs or Groups of Motifs Over- or Underrepresented Among Sample Classes
| Motif/Cluster ID | Sequence/Consensus | P Value (corrected) | Sample Class Proportion (n) | |||
|---|---|---|---|---|---|---|
| Controls (n = 25) | CFS (n = 25) | ADCLS (n = 13) | SLE (n = 11) | |||
| motif_11947 | CQSYDSSLSGYVF (BCR) | .006 (.006) | 0.24 (6) | 0.52 (13) | 0.23 (3) | 0.18 (2) |
| cluster13_2782 | cssytssstlyvf (BCR) | .014 (.013) | 0.76 (19) | 0.84 (21) | 0.54 (7) | 0.82 (9) |
| cluster11_285 | CmIWHssawvf (BCR) | .031 (.032) | 0.56 (14) | 0.36 (9) | 0.31 (4) | 0.36 (4) |
| motif_2026 | CMIWHSSAWVF (BCR) | .033 (.034) | 0.32 (8) | 0.28 (7) | 0.23 (3) | 0 (0) |
| cluster14_522 | CASslggsTDTQYF (TCR) | .036 (.035) | 0.4 (10) | 0.4 (10) | 0.38 (5) | 0.09 (1) |
| Motif/Cluster | P Value (corrected) | Controls (n = 25) | CFS + ACDLS (n = 38) | |||
| cluster13_2702 | CsSYAGsnnX (BCR) | .015 (0.015) | 0.24 (6) | 0.5 (19) | ||
| cluster12_656 | CcsyagsstwvF (BCR) | .02 (0.021) | 0.64 (16) | 0.87 (33) | ||
| cluster11_1320 | CASssXeTQYF (BCR) | .027 (0.027) | 0.2 (5) | 0.42 (16) | ||
All BCR Motifs Identified were associated with the light chain; the TCR Motif Identified was associated with the beta chain. The boldface text denotes the sample class containing the signfiicantly overrepresented or underrepresented motif.
Abbreviations: ADCLS, alternatively diagnosed chronic Lyme syndrome; BCR, B-cell receptor; CFS, chronic fatigue syndrome; SLE, systemic lupus erythematosus; TCR, T-cell receptor.