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Yeast and human RAS proteins present a highly conserved G domain, which is responsible for GTP/GDP binding. Human RAS proteins are also highly similar among them, HRAS showing 91% of amino acid identity in the G-domain to NRAS and 93% to KRAS. Yeast Ras proteins are bigger, having more than 100 extra amino acids, but still present around 60% amino acid identity in the G-domain to human RAS proteins.
