Table 4.

Associations Between Continuous (HRs per 50% Increase in Osteoprotegerin) or Quartiles of Osteoprotegerin at Baseline (n=5135) and 1 Month (n=4233) and Outcome

Model	Time	Cardiovascular Death		MI		Stroke
		HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value
1	Baseline	1.47 (1.31–1.64)	<0.0001	1.19 (1.07–1.33)	0.0019	1.21 (0.98–1.50)	0.0773
	1 Mo	1.87 (1.48–2.35)	<0.0001	1.50 (1.25–1.78)	<0.0001	1.76 (1.23–2.51)	0.0019
2	Baseline	1.25 (1.10–1.42)	0.0007	1.11 (0.98–1.25)	0.1054	1.10 (0.86–1.39)	0.4460
	1 Mo	1.30 (0.99–1.70)	0.0603	1.22 (1.00–1.50)	0.0517	1.55 (1.02–2.34)	0.0384
3	Baseline	1.05 (0.92–1.22)	0.4604	1.09 (0.95–1.26)	0.2037	1.09 (0.83–1.43)	0.5330
	1 Mo	1.05 (0.74–1.50)	0.7886	1.20 (0.94–1.53)	0.1399	1.25 (0.74–2.12)	0.4047
4	Baseline	1.04 (0.90–1.20)	0.6005	1.09 (0.95–1.25)	0.2382	1.08 (0.82–1.41)	0.5947
	1 Mo	0.90 (0.63–1.27)	0.5414	1.16 (0.91–1.49)	0.2255	1.22 (0.72–2.08)	0.4567
5	Baseline	0.97 (0.84–1.12)	0.7054	1.04 (0.90–1.20)	0.5700	1.09 (0.83–1.43)	0.5484
	1 Mo	0.88 (0.63–1.24)	0.4753	1.14 (0.90–1.46)	0.2835	1.22 (0.72–2.08)	0.4567
6	Baseline	0.90 (0.78–1.05)	0.1853	0.99 (0.86–1.15)	0.9088	1.16 (0.68–1.98)	0.5785
	1 Mo	0.89 (0.64–1.25)	0.5092	1.14 (0.89–1.46)	0.2995	1.49 (0.96–2.29)	0.0722

CI indicates confidence interval; HR, hazard ratio; and MI, myocardial infarction. Models are described in the Statistical Analysis section in the Methods.