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. 2018 Jan 13;7(2):e007148. doi: 10.1161/JAHA.117.007148

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Effect of probenecid on contractility of cardiomyocytes. A, Representative figure of attached cardiomyocytes. B and D, Force‐pCa curves generated from myocytes of saline, isoproterenol (Iso), and probenecid. C and E, Calcium sensitivity of cardiomyocytes from hearts treated with saline, Iso, and probenecid. F, Hill coefficient as an index of cooperative activation of the cardiomyocytes from hearts treated with saline, Iso, and probenecid. (*P<0.05). pCa indicates calcium sensitivity.