Table 4.
Adjustedc Hazard Ratios of Cardiovascular Disease Across Hemoglobin and eGFR/ACR Categories
| Hemoglobin Categories Adjusted Hazard Ratio (95% CI) | All | |||
|---|---|---|---|---|
| High Hemoglobin | Normal Hemoglobin | Anemia | ||
| eGFRa, mL/min per 1.73 m2 | ||||
| ≥90 | 1.13 (0.74–1.72) | 1 [Reference] | 1.03 (0.66–1.62) | 1 [Reference] |
| 60 to 89 | 1.30 (0.96–1.78) | 1.14 (0.97–1.34) | 1.55 (1.14–2.10) | 1.16 (1.00–1.35) |
| 30 to 59 | 0.61 (0.19–1.92) | 1.55 (1.20–2.00) | 2.80 (1.93–4.06) | 1.62 (1.29–2.03) |
| ACRb, mg/g | ||||
| <10 | 0.95 (0.70–1.28) | 1 [Reference] | 1.38 (1.07–1.76) | 1 [Reference] |
| 10 to 29 | 2.05 (1.26–3.34) | 1.40 (1.15–1.71) | 2.66 (1.71–4.13) | 1.51 (1.27–1.80) |
| ≥30 | 2.43 (1.39–4.24) | 2.13 (1.71–2.66) | 2.07 (1.23–3.50) | 2.06 (1.69–2.52) |
| All | 1.06 (0.84–1.35) | 1 [Reference] | 1.38 (1.12–1.70) | |
ACR indicates albumin‐to‐creatinine ratio; CI, confidence interval; eGFR, estimated glomerular filtration rate.
a
P‐for‐interaction (eGFR): 0.072.
b
P‐for‐interaction (ACR): 0.262.
c
The model was adjusted for age, race, body mass index, smoking status, alcohol consumption, education level, hypertension, diabetes mellitus, past coronary disease, past stroke, chronic obstructive pulmonary disease, and the ACR categories for the analysis of eGFR and the eGFR categories for the analysis of ACR.