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. 2018 Jan 18;7(2):e007626. doi: 10.1161/JAHA.117.007626

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Schematic summary. Striatal hemorrhage–induced impairment of the nigrostriatal pathway, including DA neurons and projection fibers from the SN to striatum. Microtubule depolymerization was an important pathological factor in nigrostriatal pathway damage, which contributes to motor function deficits and blocked axoplasmic transport. The microtubule stabilizing agent epoB can alleviate pathological lesions in the nigrostriatal pathway and improve motor function by maintaining microtubule stability via increased expression of acetylated α‐tubulin. DA indicates dopamine; epoB, epothilone B; LV, lateral ventricle; SN, substantia nigra; VTA, ventral tegmental area.