Table 3.
EXPT (n=157)a | CTRL (n=130)a | P Value | Adjusted Differences in Means (95% CI)b | P Value | |
---|---|---|---|---|---|
Systolic function | |||||
MAPSE, mm | 12.4 (1.9) | 13.3 (1.7) | <0.001 | −0.9 (−1.4 to −0.4) | <0.001 |
Shortening fraction | 0.36 (0.04) | 0.34 (0.06) | <0.001 | 0.02 (0.009–0.03) | 0.001 |
Septal | |||||
TDI s′, cm/s | 6.7 (1.0) | 6.6 (0.7) | 0.50 | −0.1 (−0.4 to 0.1) | 0.30 |
MPI’ | 0.44 (0.07) | 0.45 (0.07) | 0.16 | −0.01 (−0.03 to 0.009) | 0.26 |
Lateral | |||||
TDI s′, cm/s | 8.3 (1.4) | 9.1 (1.4) | <0.001 | −1.0 (−1.4 to −0.6) | <0.001 |
MPI’ | 0.43 (0.06) | 0.42 (0.07) | 0.18 | 0.009 (−0.009 to 0.03) | 0.34 |
Diastolic function | |||||
Mitral valve E, cm/s | 90.7 (13.1) | 88.1 (12.1) | 0.08 | 0.8 (−2.3 to 3.9) | 0.62 |
Mitral valve A, cm/s | 47.5 (11.1) | 45.9 (8.6) | 0.17 | 0.8 (−1.7 to 3.3) | 0.52 |
Septal | |||||
Mitral e′, cm/s | 12.4 (1.4) | 12.1 (1.3) | 0.11 | 0.1 (−0.3 to 0.5) | 0.58 |
Mitral a′, cm/s | 4.6 (1.3) | 4.4 (0.9) | 0.30 | −0.06 (−0.4 to 0.2) | 0.72 |
E/e′ | 7.4 (1.3) | 7.3 (1.1) | 0.59 | 0.04 (−0.3 to 0.4) | 0.83 |
IVCT, ms | 60 (12) | 65 (13) | 0.0008 | −4.5 (−7.8 to −1.2) | 0.008 |
IVRT, ms | 57 (10) | 56 (8) | 0.65 | −0.7 (−2.9 to 1.6) | 0.57 |
Lateral | |||||
Mitral e′, cm/s | 16.5 (2.4) | 17.8 (2.5) | <0.001 | −1.6 (−2.3 to −0.9) | <0.001 |
Mitral a′, cm/s | 5.2 (1.4) | 5.2 (1.1) | 0.94 | −0.5 (−0.8 to −0.2) | 0.003 |
E/e′ | 5.7 (1.2) | 5.0 (1.0) | <0.001 | 0.6 (0.3 to 0.9) | <0.001 |
IVCT, ms | 61 (12) | 63 (13) | 0.17 | −1.8 (−5.2 to 1.7) | 0.31 |
IVRT, ms | 57 (11) | 53 (9) | 0.007 | 1.8 (−0.8 to 4.6) | 0.18 |
Data are shown as mean (SD). CI indicates confidence interval; CTRL, control (born at term); E/e′, transmitral early diastolic velocity indexed to mitral annular early diastolic velocity; EXPT, extremely preterm; IVCT, mitral annular isovolumic contraction time, IVRT, mitral annular isovolumic relaxation time; MAPSE, mitral annular plane systolic excursion; mitral a′, mitral annular late diastolic velocity; mitral e′, mitral annular early diastolic velocity; mitral valve A, transmitral valve late diastolic velocity; mitral valve E, transmitral valve early diastolic velocity; MPI’, tissue Doppler imaging–derived myocardial performance index; TDI s′, tissue Doppler imaging–derived mitral annular systolic ejection velocity.
Crude values.
Adjusted for site.