Skip to main content
. 2018 Jan 20;7(2):e007742. doi: 10.1161/JAHA.117.007742

Table 3.

Left Heart Function in 6.5‐Year‐Old EXPT and CTRL Children

EXPT (n=157)a CTRL (n=130)a P Value Adjusted Differences in Means (95% CI)b P Value
Systolic function
 MAPSE, mm 12.4 (1.9) 13.3 (1.7) <0.001 −0.9 (−1.4 to −0.4) <0.001
 Shortening fraction 0.36 (0.04) 0.34 (0.06) <0.001 0.02 (0.009–0.03) 0.001
 Septal
TDI s′, cm/s 6.7 (1.0) 6.6 (0.7) 0.50 −0.1 (−0.4 to 0.1) 0.30
 MPI’ 0.44 (0.07) 0.45 (0.07) 0.16 −0.01 (−0.03 to 0.009) 0.26
 Lateral
 TDI s′, cm/s 8.3 (1.4) 9.1 (1.4) <0.001 −1.0 (−1.4 to −0.6) <0.001
 MPI’ 0.43 (0.06) 0.42 (0.07) 0.18 0.009 (−0.009 to 0.03) 0.34
Diastolic function
 Mitral valve E, cm/s 90.7 (13.1) 88.1 (12.1) 0.08 0.8 (−2.3 to 3.9) 0.62
 Mitral valve A, cm/s 47.5 (11.1) 45.9 (8.6) 0.17 0.8 (−1.7 to 3.3) 0.52
 Septal
 Mitral e′, cm/s 12.4 (1.4) 12.1 (1.3) 0.11 0.1 (−0.3 to 0.5) 0.58
 Mitral a′, cm/s 4.6 (1.3) 4.4 (0.9) 0.30 −0.06 (−0.4 to 0.2) 0.72
 E/e′ 7.4 (1.3) 7.3 (1.1) 0.59 0.04 (−0.3 to 0.4) 0.83
 IVCT, ms 60 (12) 65 (13) 0.0008 −4.5 (−7.8 to −1.2) 0.008
 IVRT, ms 57 (10) 56 (8) 0.65 −0.7 (−2.9 to 1.6) 0.57
 Lateral
 Mitral e′, cm/s 16.5 (2.4) 17.8 (2.5) <0.001 −1.6 (−2.3 to −0.9) <0.001
 Mitral a′, cm/s 5.2 (1.4) 5.2 (1.1) 0.94 −0.5 (−0.8 to −0.2) 0.003
 E/e′ 5.7 (1.2) 5.0 (1.0) <0.001 0.6 (0.3 to 0.9) <0.001
 IVCT, ms 61 (12) 63 (13) 0.17 −1.8 (−5.2 to 1.7) 0.31
 IVRT, ms 57 (11) 53 (9) 0.007 1.8 (−0.8 to 4.6) 0.18

Data are shown as mean (SD). CI indicates confidence interval; CTRL, control (born at term); E/e′, transmitral early diastolic velocity indexed to mitral annular early diastolic velocity; EXPT, extremely preterm; IVCT, mitral annular isovolumic contraction time, IVRT, mitral annular isovolumic relaxation time; MAPSE, mitral annular plane systolic excursion; mitral a′, mitral annular late diastolic velocity; mitral e′, mitral annular early diastolic velocity; mitral valve A, transmitral valve late diastolic velocity; mitral valve E, transmitral valve early diastolic velocity; MPI’, tissue Doppler imaging–derived myocardial performance index; TDI s′, tissue Doppler imaging–derived mitral annular systolic ejection velocity.

a

Crude values.

b

Adjusted for site.