Table 2.
Variable | Event | Person‐Years | Ratea | Crude HR (95% CI) | Adjusted HRb (95% CI) |
---|---|---|---|---|---|
Stroke | |||||
No | 1925 | 8 096 035 | 2.38 | 1.00 | 1.00 |
Hemorrhagic stroke | 246 | 445 868 | 5.52 | 2.27 (1.99, 2.59)c | 1.87 (1.62, 2.15)c |
Ischemic stroke | 1894 | 2 602 413 | 7.28 | 2.99 (2.81, 3.19)c | 2.25 (2.08, 2.43)c |
Total | 2140 | 3 048 280 | 7.02 | 2.89 (2.71, 3.07)c | 2.20 (2.04, 2.37)c |
Age group, y | |||||
≤49 | 605 | 1 471 834 | 4.11 | 1.31 (1.19, 1.45)c | 1.35 (1.22, 1.50)c |
50–64 | 992 | 3 153 473 | 3.15 | 1.00 | 1.00 |
≥65 | 2468 | 6 519 009 | 3.79 | 1.17 (1.09, 1.26)c | 1.06 (0.98, 1.15) |
Sex | |||||
Female | 1727 | 4 830 122 | 3.58 | 1.00 | 1.00 |
Male | 2338 | 6 314 193 | 3.70 | 1.03 (0.97, 1.10) | – |
Monthly incomed | |||||
<15 000 | 1311 | 3 577 081 | 3.66 | 1.71 (1.54, 1.89)c | 1.64 (1.46, 1.85)c |
15 000–19 999 | 2241 | 5 155 646 | 4.35 | 2.04 (1.85, 2.24)c | 1.46 (1.31, 1.63)c |
≥20 000 | 513 | 2 411 588 | 2.13 | 1.00 | 1.00 |
Urbanization levele | |||||
1 (highest) | 678 | 2 861 571 | 2.37 | 1.00 | 1.00 |
2 | 1097 | 3 081 302 | 3.56 | 1.50 (1.37, 1.65)c | 1.37 (1.24, 1.51)c |
3 | 721 | 1 813 307 | 3.98 | 1.68 (1.51, 1.86)c | 1.49 (1.34, 1.66)c |
4 (lowest) | 1569 | 3 388 134 | 4.63 | 1.95 (1.79, 2.14)c | 1.58 (1.43, 1.74)c |
Occupation categoryf | |||||
Office worker | 1325 | 4 788 374 | 2.77 | 1.00 | 1.00 |
Manual laborer | 2154 | 4 816 219 | 4.47 | 1.62 (1.51, 1.73)c | 1.31 (1.20, 1.43)c |
Other | 586 | 1 539 723 | 3.81 | 1.37 (1.24, 1.51)c | 1.01 (0.91, 1.13) |
Comorbidity | |||||
Schizophrenia | |||||
No | 4023 | 11 105 894 | 3.62 | 1.00 | 1.00 |
Yes | 42 | 38 421 | 10.9 | 2.96 (2.18, 4.01)c | 1.98 (1.46, 2.70)c |
Depression before stroke | |||||
No | 3844 | 11 043 613 | 3.48 | 1.00 | 1.00 |
Yes | 221 | 100 703 | 22.0 | 6.11 (5.33, 6.99)c | 3.37 (2.91, 3.89)c |
Poststroke depression | |||||
No | 3852 | 10 990 993 | 3.50 | 1.00 | 1.00 |
Yes | 213 | 153 323 | 13.9 | 4.05 (3.53, 4.65)c | 2.81 (2.44, 3.24)c |
Alcohol‐related illness | |||||
No | 3936 | 11 051 763 | 3.56 | 1.00 | 1.00 |
Yes | 129 | 92 552 | 13.9 | 3.81 (3.19, 4.54)c | 2.09 (1.72, 2.52)c |
Anxiety | |||||
No | 3944 | 11 070 435 | 3.56 | 1.00 | 1.00 |
Yes | 121 | 73 880 | 16.4 | 4.52 (3.77, 5.42)c | 1.72 (1.42, 2.08)c |
Mental disorders | |||||
No | 3939 | 10 890 990 | 3.62 | 1.00 | 1.00 |
Yes | 126 | 253 325 | 4.97 | 1.29 (1.08, 1.55)g | 0.81 (0.67, 1.00) |
Insomnia | |||||
No | 3858 | 11 000 255 | 3.51 | 1.00 | 1.00 |
Yes | 207 | 144 061 | 14.4 | 3.95 (3.44, 4.55)c | 1.79 (1.54, 2.08)c |
Cognitive dysfunction | |||||
No | 4042 | 11 099 183 | 3.64 | 1.00 | 1.00 |
Yes | 23 | 45 133 | 5.10 | 1.30 (0.86, 1.96) | 0.76 (0.50, 1.15) |
Dementia after stroke | |||||
No | 3983 | 10 830 139 | 3.68 | 1.00 | 1.00 |
Yes | 82 | 314 176 | 2.61 | 0.71 (0.57, 0.88)g | 0.42 (0.33, 0.52)c |
Diabetes mellitus | |||||
No | 3292 | 9 730 782 | 3.38 | 1.00 | 1.00 |
Yes | 773 | 1 413 534 | 5.47 | 1.64 (1.52, 1.78)c | 1.28 (1.18, 1.39)c |
Chronic obstructive pulmonary disease | |||||
No | 3682 | 10 668 608 | 3.45 | 1.00 | 1.00 |
Yes | 383 | 475 707 | 8.05 | 2.21 (1.99, 2.46)c | 1.35 (1.20, 1.52)c |
Asthma | |||||
No | 3825 | 10 873 179 | 3.52 | 1.00 | 1.00 |
Yes | 240 | 271 137 | 8.85 | 2.42 (2.12, 2.76)c | 1.33 (1.15, 1.53)c |
Coronary artery disease | |||||
No | 3370 | 10 125 179 | 3.33 | 1.00 | 1.00 |
Yes | 695 | 1 019 136 | 6.82 | 1.98 (1.83, 2.15)c | 1.23 (1.13, 1.35)c |
Hypertension | |||||
No | 2411 | 8 422 637 | 2.86 | 1.00 | 1.00 |
Yes | 1654 | 2721 678 | 6.08 | 2.06 (1.93, 2.19)c | 1.11 (1.03, 1.20)g |
CI indicates confidence interval; HR, hazard ratio; NTD, New Taiwan dollars.
Incidence rate per 10 000 person‐years.
Multivariable analysis included age, monthly income, urbanization level, and comorbidity of schizophrenia, depression before stroke, poststroke depression, alcohol‐related illness, anxiety, mental disorders, insomnia, cognitive dysfunction, dementia after stroke, diabetes mellitus, chronic obstructive pulmonary disease, asthma, coronary artery disease, and hypertension.
P<0.001.
In NTD, where 1 NTD is equal to 0.03 US dollars.
The urbanization level of residential areas was determined by dividing the population density into 4 levels, with level 1 the most urbanized and level 4 the least urbanized.
Other occupation categories included those who were primarily retired, unemployed, and on low income.
P<0.01.