Table 2.
Serum or Plasma Values Before and After 1 or 2 Weeks of Diuretic Administration
| Parameter | Before (Day ‐1) | Dapagliflozin (Day 8) | Before (Day ‐1) | Bumetanide (Day 8) | Before (Day ‐1) | Dapagliflozin+Bumetanide (Day 8) | Dapagliflozin+Bumetanide (Day 14) |
|---|---|---|---|---|---|---|---|
| SNa, mmol·L−1 | 137.9±0.5 | 138.1±0.4 | 137.7±0.3 | 137.8±0.3 | 138.1±0.4 | 137.1±0.4* | 138.3±0.5 |
| Sosm, mOsmol·L−1 | 283.5±0.8 | 285.4±0.7* | 283.9±1.0 | 285.4±0.9 | 284.4±0.9 | 283.3±0.9 | 284.3±1.0 |
| Serum glucose, mg·dL−1 | 86.3±2.0 | 82.3±2.0† | 88.4±2.2 | 85.5±1.8* | 87.2±1.4 | 82.4±2.5* | 84.0±1.7* |
| SK, mmol·L−1 | 4.5±0.09 | 4.4±0.08 | 4.4±0.07 | 4.1±0.09* | 4.6±0.1 | 4.1±0.07‡ | 4.0±0.008‡ |
| Surate, mmol·L−1 | 5.5±0.3 | 3.5±0.2‡ | 5.9±0.3 | 6.1±0.4* | 5.4±0.4 | 4.2±0.3† | 4.3±0.3* |
| SCr, mg·dL−1 | 0.9±0.05 | 1.0±0.04‡ | 0.9±0.04 | 1.0±0.05* | 0.9±0.05 | 1.0±0.05‡ | 1.0±0.05‡ |
| Plasma renin activity, ng·mL−1·h−1 | 3.4±0.7 | 3.4±0.9 | 3.6±0.8 | 7.8±1.8* | 5.6±1.2 | 9.8±2.0 | 6.2±1.1 |
Data are given as mean±SEM values before and after 1 week of dapagliflozin alone (10 mg·d−1), or 1 week of bumetanide alone (mg·d−1), or after 1 and 2 weeks of dapagliflozin and bumetanide combined. SCr indicates serum creatinine; SK, serum potassium; SNa, serum sodium; Sosm, serum osmoles; and Surate, serum urate.
*P<0.05, † P<0.01, ‡ P<0.005 (compared with before).