Table 3.
Adjusted Hazard Ratio (95% CI) of Adverse Outcomes After Incident MI According to Life's Simple 7 Score Among Patients With MI
| Variable | Score of Life's Simple 7 | ||||
|---|---|---|---|---|---|
| 0–3 (N=77) | 4–6 (N=445) | 7–9 (N=593) | ≥10 (N=162) | P Value for Trend | |
| Composite outcome | |||||
| Cases | 71 | 345 | 421 | 81 | |
| Model 1 | 1 (Reference) | 0.80 (0.61–1.04) | 0.73 (0.56–0.96) | 0.52 (0.37–0.75) | <0.001 |
| Model 2a | 1 (Reference) | 0.80 (0.61–1.04) | 0.73 (0.56–0.96) | 0.53 (0.37–0.75) | 0.001 |
| Model 2b (N=1102) | 1 (Reference) | 0.82 (0.60–1.11) | 0.78 (0.57–1.07) | 0.57 (0.39–0.84) | 0.007 |
| All‐cause mortality | |||||
| Cases | 57 | 273 | 287 | 44 | |
| Model 1 | 1 (Reference) | 0.78 (0.58–1.05) | 0.51 (0.38–0.70) | 0.32 (0.21–0.49) | <0.001 |
| Model 2a | 1 (Reference) | 0.78 (0.58–1.05) | 0.52 (0.38–0.70) | 0.32 (0.21–0.49) | <0.001 |
| Model 2b (N=1102) | 1 (Reference) | 0.84 (0.59–1.19) | 0.60 (0.41–0.86) | 0.34 (0.21–0.56) | <0.001 |
| Cardiovascular mortality | |||||
| Cases | 32 | 112 | 104 | 10 | |
| Model 1 | 1 (Reference) | 0.79 (0.52–1.20) | 0.57 (0.36–0.88) | 0.28 (0.13–0.61) | <0.001 |
| Model 2a | 1 (Reference) | 0.79 (0.52–1.20) | 0.57 (0.36–0.88) | 0.28 (0.13–0.61) | <0.001 |
| Model 2b (N=1102) | 1 (Reference) | 0.83 (0.50–1.39) | 0.68 (0.40–1.18) | 0.32 (0.14–0.74) | 0.007 |
| Recurrent MI | |||||
| Cases | 24 | 113 | 131 | 24 | |
| Model 1 | 1 (Reference) | 0.92 (0.58–1.45) | 0.79 (0.49–1.26) | 0.59 (0.32–1.10) | 0.048 |
| Model 2a | 1 (Reference) | 0.93 (0.59–1.46) | 0.81 (0.51–1.30) | 0.62 (0.33–1.15) | 0.075 |
| Model 2b (N=1102) | 1 (Reference) | 1.04 (0.60–1.82) | 0.91 (0.51–1.62) | 0.74 (0.36–1.51) | 0.213 |
| Heart failure | |||||
| Cases | 53 | 211 | 254 | 53 | |
| Model 1 | 1 (Reference) | 0.72 (0.52–0.98) | 0.68 (0.49–0.95) | 0.60 (0.39–0.92) | 0.041 |
| Model 2a | 1 (Reference) | 0.72 (0.52–0.98) | 0.69 (0.50–0.95) | 0.61 (0.40–0.93) | 0.050 |
| Model 2b (N=1102) | 1 (Reference) | 0.77 (0.54–1.10) | 0.78 (0.54–1.13) | 0.71 (0.45–1.12) | 0.320 |
| Stroke | |||||
| Cases | 7 | 55 | 58 | 9 | |
| Model 1 | 1 (Reference) | 1.74 (0.78–3.89) | 1.46 (0.64–3.31) | 1.06 (0.37–3.05) | 0.606 |
| Model 2a | 1 (Reference) | 1.76 (0.79–3.93) | 1.42 (0.62–3.22) | 1.03 (0.36–2.95) | 0.505 |
| Model 2b (N=1102) | 1 (Reference) | 1.72 (0.67–4.40) | 1.70 (0.65–4.44) | 1.27 (0.40–4.07) | 0.914 |
Model 1: adjusted for age at MI; sex; race; calendar year of incident MI (<1995, 1995–2004, and ≥2005); history of heart failure, stroke, coronary artery bypass graft, peripheral artery disease, kidney dysfunction, hypertension, and diabetes mellitus; and current smoking at admission. Model 2a: adjusted for model 1+health insurance at baseline. Model 2b: adjusted for model 1+health insurance at admission. CI indicates confidence interval; and MI, myocardial infarction.