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. 2018 Feb 16;7(4):e007675. doi: 10.1161/JAHA.117.007675

Figure 6.

Figure 6

Nitric oxide (NO) and reactive oxygen species (ROS) production in male and female resistance vessels in response to risk factors. Protein expression of total endothelial nitric oxide synthase (eNOS) and serine 1177 phosphorylated eNOS (p‐eNOS) in small mesenteric arteries of control, obese, and hyperlipidemic male (A and B) and female (C and D) EC‐MR–intact mice (EC‐MR +/+) or knockout mice (EC‐MR −/−). NO levels were evaluated by quantification of DAF‐2 DA (4,5‐diaminofluorescein diacetate) fluorescence, and ROS production was evaluated by quantification of DHE (dihydroethidium [hydroethidine]) fluorescence in mesenteric artery sections from male (E and G) and female (F and H) mice. Two‐factor ANOVA: *P<0.05. EC‐MR indicates mineralocorticoid receptors in endothelial cells.