Table 2.
Comparison of Diagnostic Performance for Predicting Hemodynamically Significant Stenosis in Single‐Vessel Versus Multivessel Disease
| Measure | Per‐Patient Level | Per‐Vessel Level | ||||
|---|---|---|---|---|---|---|
| Single‐Vessel (n=25) | Multivessel (n=67) | Single‐Vessel (n=75) | Multivessel (n=201) | |||
| Perfusion CMR (95% CI) | Perfusion CMR (95% CI) | Combined Perfusion CMR/CS Blood Flow (95% CI) | Perfusion CMR (95% CI) | Perfusion CMR (95% CI) | Combined Perfusion CMR/CS Blood Flow (95% CI) | |
| Functional CAD, % | 48.0 | 77.6 | 77.6 | 16.0 | 47.3 | 47.3 |
| Sensitivity, % |
83 (52–98) 10/12 |
79 (65–89) 41/52 |
92 (82–98) 48/52 |
83 (52–98) 10/12 |
64 (54–74) 61/95 |
86 (78–93) 82/95 |
| Specificity, % |
85 (55–98) 11/13 |
73 (45–92) 11/15 |
73 (45–92) 11/15 |
95 (87–99) 60/63 |
81 (72–88) 85/106 |
73 (63–81) 77/106 |
| NPV, % |
85 (55–98) 11/13 |
50 (28–72) 11/22 |
73 (44–93) 11/15 |
97 (89–100) 60/62 |
72 (63–80) 85/119 |
86 (77–92) 77/90 |
| PPV, % |
83 (52–98) 10/12 |
91 (79–98) 41/45 |
92 (82–98) 48/52 |
77 (46–95) 10/13 |
75 (65–84) 61/82 |
74 (65–82) 82/111 |
| LR (+) | 5.42 | 2.96 | 3.46 | 17.5 | 3.4 | 3.15 |
| LR (−) | 0.20 | 0.29 | 0.10 | 0.18 | 0.44 | 0.19 |
| AUC | 0.93 (0.76–0.99) | 0.76 (0.64–0.86) | 0.88 (0.80–0.97) | 0.95 (0.87–0.99) | 0.80 (0.73–0.85) | 0.84 (0.70–0.90) |
Values for sensitivity, specificity, PPV, NPV, and AUC are presented with 95% CI. AUC indicates area under the receiver operator characteristic curve; CAD, coronary artery disease; CI, confidence interval; CMR, cardiovascular magnetic resonance; CS, coronary sinus; LR, likelihood ratio; NPV, negative predictive value; PPV, positive predictive value.