Figure 5.

Effect of Ang‐(1‐7) on cerebral blood flow and cognitive function. Effect of Ang‐(1‐7) was estimated with the Morris water maze test. All mice underwent bilateral common carotid artery stenosis (BCAS) surgery before drug administration. The mean escape latency did not significantly change between sham mice and BCAS‐treated mice among all groups. (n=8–14 for each group). *P<0.05 vs Mas receptor knockout mice (MasKO)–BCAS with vehicle. ^† P<0.05 vs MasKO‐BCAS with Ang‐(1‐7). AT₂KO indicates angiotensin II type 2 receptor knockout mice; DKO, Mas/angiotensin II type 2 receptor double knockout mice; WT, wild‐type mice.