Table 1.

Direct Evidence for Emergence of Serotypes by Recombination.

Serogroup	Serotype(s)	Gene(s) Affected	Likely Source
6	6C	wciN	Unknown (homolog in 39X)
6	6D	wciP, wzy, wzx	6B-II
19	19B/19C	wchU	Streptococcus mitis
10	10C	wcrW	10A
34/35	47F	whaI	47A
16/28	28A	wciU	Unknown
22	22A/22F	wcwC	Unknown

Note.—The table summarizes the cases in recombinations directly detected in our approach were associated with the emergence of new serotypes. In some cases, the direction of recombination could not be established; in this case, multiple serotypes were given in the second column. Details of the analysis are given in Supplementary Material online.