Table 1.
Correlation of Inflammatory Mediators With Borrelia Immunoglobulin G Antibody Responses in Patients With Erythema Migrans or Lyme Arthritisa
| Mediator | Borrelia Antibody Responses (IgG) | ||
|---|---|---|---|
| EM Serum (n = 29) |
LA Serum (n = 79) |
LA Synovial Fluid (n = 44) |
|
| Innate responses | |||
| CCL2 | 0.4 | 0.1 | –0.1 |
| 0.06 | 0.5 | 0.3 | |
| CCL3 | 0.2 |
<–0.1 | –0.2 |
| 0.4 | 0.7 | 0.3 | |
| IL-1β | 0.1 | –0.1 | <–0.1 |
| 0.5 | 0.3 | 1 | |
| IL-6 | 0.2 | –0.1 | <0.1 |
| 0.3 | 0.2 | 1 | |
| IL-8 | –0.1 | <0.1 | r = –0.5 |
| 0.7 | 0.8 | P = .003 | |
| IL-10 | 0.2 | <–0.1 | <0.1 |
| 0.3 | 0.6 | 0.8 | |
| TNF | r = 0.4 | <–0.1 | -0.1 |
| P = .04 | 0.6 | 0.4 | |
| IFN-α | 0.3 | <0.1 | <0.1 |
| 0.08 | 0.6 | 0.9 | |
| TH1 adaptive responses | |||
| IFN-γ | 0.1 | <–0.1 | <0.1 |
| 0.7 | 0.7 | 1 | |
| CXCL9 | r = 0.4 | <0.1 | –0.2 |
| P = .03 | 1 | 0.3 | |
| CXCL10 | r = 0.4 | <–0.1 | <–0.1 |
| P = .02 | 0.5 | 0.6 | |
| IL-12p40 | r = 0.4 | –0.1 | <0.1 |
| P = .03 | 0.4 | 0.9 | |
| IL-12p70 | 0.3 | <0.1 | 0.2 |
| 0.1 | 0.7 | 0.3 | |
| CCL19 | r = 0.4 | 0.2 | –0.2 |
| P = .04 | 0.07 | 0.2 | |
| TH17 adaptive responses | |||
| IL-17A | r = 0.3 | <–0.1 | –0.2 |
| P = .07 | 0.6 | 0.2 | |
| IL-17F | r = .4 | r = 0.3 | 0.2 |
| P = .02 | P = .02 | 0.3 | |
| IL-23 | r = 0.4 | 0.2 | 0.2 |
| P = .02 | 0.2 | 0.4 | |
| IL-25 | r = 0.5 | <0.1 | 0.2 |
| P = .01 | 0.5 | 0.2 | |
| IL-27 | r = 0.4 | <0.1 | 0.2 |
| P = .02 | 0.5 | 0.2 | |
Abbreviations: EM, erythema migrans; IFN-y, interferon gamma; IgG, immunoglobulin G; IL, interleukin; LA, Lyme arthritis; TH1, T-helper cell 1; TH17, T-helper cell 17; TNF, tumor necrosis factor.
Correlations between the levels of inflammatory mediators (pg/mL) and Borrelia antibodies (optical density, OD450) were performed using a Pearson correlation test. For each mediator, r coefficient is presented in the first line, and P value in the second line. Values that did not reach significance are in plain text and do not contain "r" or "P" label. Values in bold reflect statistically significant correlations based on P ≤ .05 with Benjamini-Hochberg correction for multiple comparisons (false discovery rate ≤ 0.1).