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. 2018 Feb 1;10(2):60. doi: 10.3390/v10020060

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Implications of resistant genotypes on recommended first- and second-line regimens: (A) prevalence of resistance to recommended first-line NNRTIs (blue) and NRTIs (red) among participants harboring NNRTI (N = 72) and NRTI (N = 64) resistance, respectively; and (B) burden of multi-NRTI resistance among participants harboring NRTI resistance (N = 64). Resistance to individual drugs was defined using the Stanford Drug Resistance Database, where genotypes exhibiting any level of reduced susceptibility to a given drug were considered “resistant” [51,52].