Table 2.
Inhibitor and substrate complexes of RdRPs from different viruses (listed in Table 1) determined to a resolution better than 2.5 Å.
| Group | Family | Structures with Ligands | RdRps Complexed with nucleoside triphosphate (NTP) and Their Derivatives | PDB IDs of RdRp-NTP Complexes | RdRps Complexed with Inhibitors |
|---|---|---|---|---|---|
| dsRNA viruses | Reoviridae and Birnaviridae | 5 | 2 | 1MWH,1N35 | 0 |
| Bacteriophages | Cystoviridae and Leviviridae | 9 | 2 | 3AVX, 1UVK | 0 |
| (+) ssRNA Viruses | Caliciviridae | 6 | 4 | 3B5N, 3BS0, 3H5X, 3H5Y | 1 |
| (+) ssRNA Viruses | Flaviviridae | 133 | 5 | 2XI3, 1GX6, 1GX5, 4HDH, 4HDG | 120 |
| (+) ssRNA Viruses | Picornaviridae | 40 | 7 | 1RA7, 2ILZ, 2IM0, 2IM1, 2IM2, 3OLB, 5F8I | 0 |
| (−) ssRNA Viruses | Ortho-myxoviridae, Rhabdoviridae | 5 | 0 | NA | 0 |