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. 2018 Feb 23;10(2):90. doi: 10.3390/v10020090

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Mechanism of apoptosis induction by Vesicular stomatitis virus (VSV) in the infected cell. The figure depicts possible mechanisms by which VSV could induce apoptosis in infected cells. Depending on the context, either the intrinsic or extrinsic pathway of apoptosis is activated. Mcl-1: Induced myeloid leukemia cell differentiation protein 1; Apaf-1: Apoptotic protease activating factor 1; Bak: BCL2 antagonistic/killer; Bcl-XL: B-cell lymphoma-extra-large; eIF4F: eukaryotic initiation factor 4F; Nup98: nucleoprotein 98; Rae 1: ribonucleic acid export 1.