Table 1.
Immune Correlates Proposed to Be Important in Prevention of Maternofetal Cytomegalovirus Transmission
| Innate Immunity |
|---|
| Innate immunity: cells |
| • Maternal NK cells |
| • Decidual (uterine) NK cells |
| • Memory NK cells |
| • Phagocytic cells (neutrophils, macrophages) |
| • Placental macrophages (Hofbauer cells) |
| Innate immunity: mediators |
| • Chemokines |
| • Cytokines (IFN-γ, IL-12, TNF-α) |
| • β-defensins |
| • Micro RNA (miRNA) |
| Innate immunity: host genetics |
| • TLR gene/promoter polymorphisms |
| o TLR2 |
| o TLR3 |
| o TLR7 |
| • Mannose-binding lectin gene polymorphisms |
| Adaptive Immunity |
| Adaptive immunity: T cells |
| • CD4+ T cells |
| o pp65 (ppUL83)-specifica responses |
| o IE1, IE2-specific responses |
| • CD8+ T cells |
| • Gamma delta T cells |
| Adaptive immunity: antibody |
| • Serum neutralizing antibody |
| o Neutralizing antibody targeting glycoprotein B |
| o Neutralizing antibody targeting pentameric complex of gH/gL/UL128/130/131 |
| •High-avidity antibodyb |
| •Antibody-dependent cellular cytotoxicity |
Source: [7, 8 ].
Abbreviations: IFN, interferon; IL, interleukin; NK, natural killer; TLR, Toll-like receptor; TNF, tumor necrosis factor.
aSee article by Fornara et al, this issue.
bSee article by Tanimura et al, this issue.