Table 1.

Antibacterial Resistance Leadership Group Studies Addressing Unmet Needs in Gram-Positive Bacterial Infections

Study	Description	Status
PROVIDE (Prospective Validation of the Vancomycin Exposure Profile Associated With Optimal Outcomes Among Patients With MRSA Bloodstream Infections)	Prospective observational study to assess the impact of vancomycin exposure profile on outcomes of patients with MRSA BSI	Completed
STAMP (Staphylococcus aureus Management Approaches), others	Clinician ranking exercise to develop a DOOR endpoint for use in SA-BSI treatment trials	Completed
	Analysis of previous SA-BSI trials using DOOR endpoint	Ongoing
	Development and validation of a quality-of-life tool for SA-BSI trials	Ongoing
	Randomized trial comparing step-down therapy strategy to standard of care for SA-BSI	Planning
Neonatal ICU cohort	Analysis of impact of adequate empiric antibiotic therapy on outcomes in neonatal staphylococcal BSI	Completed
VRE BSI (seed grant)	Multicenter prospective cohort of hematological malignancy and/ or stem-cell transplant patients with VRE BSI treated with daptomycin	Planning

Abbreviations: BSI, bloodstream infection; DOOR, desirability of outcome ranking; ICU, intensive care unit; MRSA, methicillin-resistant Staphylococcus aureus; SA, Staphylococcus aureus; VRE, vancomycin-resistant enterococci.