Table III.
Adjusted mean peak estradiol concentrations, mature oocyte count and endometrial thickness on the day of embryo transfer following ART, by alcohol and caffeine intake in 279 women (290 unique FFQs, 389 fresh ART cycles with egg retrieval) from the EARTH Study.
| Categories, range | Number of unique FFQs /cycles | Adjusted means (95% CI)a | ||
|---|---|---|---|---|
| E2 trigger levels, pmol/L | Endometrial thickness, mm | MII phase oocytes count, n | ||
| Alcohol intake, g/day | ||||
| 0.0 | 30/38 | 2243 (1446–3040) | 10.2 (8.2–12.2) | 9.8 (8.1–12.0) |
| 0.1–6.0 | 115/151 | 2052 (1584–2519) | 10.3 (9.2–11.5) | 9.6 (8.5–10.8) |
| 6.1–12.0 | 59/83 | 2048 (1502–2594) | 10.3 (8.9–11.7) | 9.2 (8.0–10.6) |
| 12.1–24.0 | 69/91 | 2024 (1471–2577) | 10.4 (8.9–11.8) | 9.8 (8.5–11.3) |
| 24.1–85.8 | 17/26 | 2022 (1039–3005) | 10.2 (7.7–12.7) | 10.4 (8.2–13.3) |
| P-trendb | 0.59 | 0.93 | 0.53 | |
| Caffeine intake, mg/day | ||||
| 0.3–50 | 88/128 | 2112 (1607–2616) | 10.1 (8.8–11.4) | 9.1 (8.0–10.3) |
| 50.1–100 | 39/47 | 1841 (1130–2552) | 10.0 (8.2–11.8) | 9.4 (7.9–11.2) |
| 101.1–200 | 94/120 | 2043 (1554–2531) | 10.4 (9.2–11.7) | 9.8 (8.7–11.1) |
| 200.1–300 | 53/71 | 2063 (1462–2663) | 10.5 (9.0–12.1) | 10.1 (8.7–11.7) |
| 300.1–642 | 16/23 | 2061 (1056–3066) | 10.7 (8.1–13.2) | 10.3 (8.1–13.3) |
| P-trendb | 0.93 | 0.16 | 0.16 | |
MII: metaphase II; E2: estradiol.
aData are presented as predictive marginal means adjusted for age, BMI, infertility diagnosis, race, smoking status, alcohol, caffeine, calories, folate and Vitamin B12 intake and dietary patterns, with continuous covariates at their mean level and categorical measures estimated at their reference level.
bTests for trend were performed using the median level of caffeine and alcohol intake in each group as a continuous variable in the model.