Table V.

Age-adjusted and multivariable odds ratios of early menopause by BMI in 1989 stratified by smoking status, Nurses’ Health Study II, 1989–2011^a.

Adiposity measure	Total	Cases	Age-adjusted model		Multivariable-adjusted modelb
			OR	95% CI	OR	95% CI
Non-smokers
BMI, 1989 (kg/m2)
<18.5	1870	75	1.22	0.96, 1.55	1.22	0.95, 1.55
18.5–22.4	23677	772	ref		ref
22.5–24.9	11247	339	0.93	0.82, 1.06	0.92	0.80, 1.04
25.0–27.4	6232	179	0.89	0.76, 1.05	0.86	0.73, 1.02
27.5–29.9	2862	78	0.85	0.67, 1.08	0.80	0.63, 1.02
30.0–34.9	3323	100	0.95	0.76, 1.17	0.88	0.71, 1.09
≥35.0	2120	80	1.20	0.95, 1.51	1.06	0.83, 1.35
Smokers
BMI, 1989 (kg/m2)
<18.5	777	50	1.48	1.09, 1.99	1.40	1.03, 1.90
18.5–22.4	11812	523	ref		ref
22.5–24.9	6310	291	1.05	0.90, 1.21	1.00	0.86, 1.15
25.0–27.4	3502	119	0.76	0.62, 0.94	0.70	0.57, 0.86
27.5–29.9	1543	44	0.64	0.47, 0.87	0.58	0.43, 0.80
30.0–34.9	1815	72	0.90	0.70, 1.16	0.78	0.61, 1.01
≥35.0	1116	57	1.18	0.89, 1.56	0.98	0.74, 1.31

^aNon-smokers n = 51 331; smokers n = 26 875; interaction P = 0.34.

^bAdjusted for age, race/ethnicity, physical activity, pack-years cigarette smoking until menopause, alcohol consumption, oral contraceptive use, parity, age at menarche and breastfeeding. See Table II footnote for categorization of covariates.