Table II.

Age-adjusted and multivariable odds ratios of early menopause by measures of adiposity, Nurses’ Health Study II, 1989–2011^a.

Adiposity measure	Total	Cases	Age-adjusted model		Multivariable-adjusted Model 1b		Multivariable-adjusted Model 2c
			OR	95% CI	OR	95% CI	OR	95% CI
BMI, 1989 (kg/m2)
<18.5	2650	125	1.30	1.07, 1.56	1.29	1.07, 1.56	1.30	1.08, 1.57
18.5–22.4	35 539	1299	ref		ref		ref
22.5–24.9	17 581	631	0.99	0.90, 1.09	0.96	0.87, 1.06	0.95	0.86, 1.04
25.0–27.4	9745	298	0.84	0.74, 0.95	0.81	0.71, 0.92	0.79	0.69, 0.89
27.5–29.9	4413	122	0.76	0.63, 0.92	0.73	0.60, 0.88	0.70	0.58, 0.84
30.0–34.9	5145	172	0.92	0.79, 1.09	0.89	0.76, 1.05	0.83	0.71, 0.98
≥35.0	3237	137	1.18	0.98, 1.42	1.13	0.94, 1.35	1.02	0.85, 1.23
Waist circumference, 1993 (inches)
<28.0	10139	325	ref		ref		ref
28.0–<30.0	7757	220	0.90	0.76, 1.08	0.89	0.75, 1.06	0.90	0.75, 1.07
30.0–<32.0	5774	154	0.87	0.71, 1.05	0.85	0.70, 1.03	0.84	0.69, 1.03
32.0–<36.0	6628	155	0.77	0.64, 0.94	0.74	0.61, 0.91	0.73	0.60, 0.89
≥36.0	5337	159	1.02	0.84, 1.23	0.97	0.80, 1.18	0.92	0.76, 1.12
Waist-hip ratio, 1993
<0.75	12210	380	ref		ref		ref
0.75–<0.80	10669	300	0.90	0.77, 1.05	0.88	0.75, 1.02	0.89	0.76, 1.03
0.80–<0.85	6752	179	0.85	0.71, 1.02	0.81	0.68, 0.97	0.81	0.67, 0.97
0.85–<0.90	3474	79	0.74	0.58, 0.95	0.71	0.55, 0.91	0.70	0.55, 0.90
≥0.90	2372	74	1.03	0.80, 1.33	0.98	0.76, 1.26	0.96	0.74, 1.23

^aBMI information in 1989; n = 78 310; waist circumference n = 35 635; waist-to-hip ratio n = 35 477.

^bAdjusted for age at baseline (continuous), race/ethnicity (non-Hispanic White, Asian, Other), physical activity (<3, 3–49, >49 MET*h/week), pack-years cigarette smoking (0, 1–10, 10–15, >15 pack-years), alcohol consumption (0, 0–10, 10–30, ≥30 g of alcohol).

^cModel 1 additionally adjusted for reproductive factors: oral contraceptive use and duration (nonuser, 1–71, ≥72 months), parity (0,1–2, ≥3 births), age at menarche (<10, 10, 11, 12, 13, 14, 15, 16, ≥17 years of age), breastfeeding status and duration (0 −1, 1–3, 3–6, ≥6 months).