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. 2017 Dec 5;35(2):473–485. doi: 10.1093/molbev/msx305

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© The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 2. — (A) ASR values of certain cancers and average annual temperatures plotted in Earth maps, aside to linear regression plots. (B) Linear regression plots, separately for each gender, for colon cancer and for all cancers. (C) Linear regression plots showing i) the high linearity between average annual temperatures (Celsius degrees) and extreme low temperatures (Celsius degrees) and ii) significant correlation between cancer ASR values and extreme low temperatures. ASR values were plotted by ascending order of eight quartiles (the darker the color the higher the incidence, quartiles can be found in supplementary table S1, Supplementary Material online). Greenland was included in the maps according cancer ASRs reported by Young et al. (2016). Average annual temperatures were plotted according an inverse ascending order (the darker the color the lower the temperature) of eight quartiles. Only countries reported by GLOBOCAN-2012 were included to linear regression analyses. Adjusted R² is above of each regression plot (both gender included for “all cancers” and “colorectal cancer” plots). Prediction probability is highly significant for all regression analyses.

Fig. 2. — (A) ASR values of certain cancers and average annual temperatures plotted in Earth maps, aside to linear regression plots. (B) Linear regression plots, separately for each gender, for colon cancer and for all cancers. (C) Linear regression plots showing i) the high linearity between average annual temperatures (Celsius degrees) and extreme low temperatures (Celsius degrees) and ii) significant correlation between cancer ASR values and extreme low temperatures. ASR values were plotted by ascending order of eight quartiles (the darker the color the higher the incidence, quartiles can be found in supplementary table S1, Supplementary Material online). Greenland was included in the maps according cancer ASRs reported by Young et al. (2016). Average annual temperatures were plotted according an inverse ascending order (the darker the color the lower the temperature) of eight quartiles. Only countries reported by GLOBOCAN-2012 were included to linear regression analyses. Adjusted R² is above of each regression plot (both gender included for “all cancers” and “colorectal cancer” plots). Prediction probability is highly significant for all regression analyses.