Table 1.
Age-Standardized Rate Mean Comparison (independent t-test, two-tailed) between Cold and Warm Countries, for the Ten Most Frequent Cancer Types Worldwide, Plus Gallbladder and Testis Cancera.
| Cancer Site | Countries Number (AAT range in °C) | Mean ASR | SD | [95% CI] | t Value | P Value |
|---|---|---|---|---|---|---|
| All cancers | 45 (−5.1 to 10.6) | 240.3644 | 61.9635 | 221.7485 258.9803 | 10.8334 | 9.49×10−18 |
| 43 (25.1 to 28.3) | 118.2488 | 41.21378 | 105.5651 130.9326 | |||
| Lung | 45 (−5.1 to 10.6) | 28.65778 | 9.817505 | 25.70827 31.60728 | 10.8496 | 8.80×10−18 |
| 43 (25.1 to 28.3) | 7.890698 | 7.998982 | 5.428974 10.35242 | |||
| Breast | 45 (−5.1 to 10.6) | 61.27778 | 26.92922 | 53.18735 69.36821 | 5.3538 | 7.06×10−7 |
| 43 (25.1 to 28.3) | 36.22326 | 15.04381 | 31.59346 40.85306 | |||
| Colorectum | 45 (−5.1 to 10.6) | 25.96 | 10.58173 | 22.7809 29.1391 | 8.4250 | 7.28×10−13 |
| 43 (25.1 to 28.3) | 9.402326 | 7.523186 | 7.087031 11.71762 | |||
| Prostate | 45 (−5.1 to 10.6) | 54.39333 | 38.2683 | 42.89626 65.8904 | 4.2772 | 4.88×10−5 |
| 43 (25.1 to 28.3) | 24.4814 | 25.84096 | 16.52872 32.43407 | |||
| Stomach | 45 (−5.1 to 10.6) | 11.00444 | 6.338876 | 9.100035 12.90885 | 6.2743 | 1.37×10−8 |
| 43 (25.1 to 28.3) | 4.52093 | 2.445848 | 3.768209 5.273651 | |||
| Liver | 45 (−5.1 to 10.6) | 6.624444 | 11.51497 | 3.164963 10.08393 | −1.1090 | 0.2705 |
| 43 (25.1 to 28.3) | 8.823256 | 6.17016 | 6.924361 10.72215 | |||
| Cervix | 45 (−5.1 to 10.6) | 13.74889 | 6.854846 | 11.68947 15.80831 | −4.1028 | 9.24×10−5 |
| 43 (25.1 to 28.3) | 22.62791 | 12.71393 | 18.71514 26.54068 | |||
| Esophagus | 45 (−5.1 to 10.6) | 4.097778 | 3.434153 | 3.066044 5.129511 | 3.3467 | 1.21×10−3 |
| 43 (25.1 to 28.3) | 2.023256 | 2.223772 | 1.33888 2.707632 | |||
| Bladder | 45 (−5.1 to 10.6) | 8.473333 | 3.937027 | 7.290519 9.656147 | 9.0700 | 3.54×10−14 |
| 43 (25.1 to 28.3) | 2.660465 | 1.501609 | 2.198338 3.122592 | |||
| Non-Hodgkin lymphoma | 45 (−5.1 to 10.6) | 6.2 | 3.370932 | 5.18726 7.21274 | 3.8072 | 2.63×10−4 |
| 43 (25.1 to 28.3) | 4.027907 | 1.658646 | 3.517451 4.538363 | |||
| Gallbladder | 45 (−5.1 to 10.6) | 1.935556 | 1.546279 | 1.471002 2.400109 | 4.7545 | 7.92×10−6 |
| 43 (25.1 to 28.3) | 0.7186047 | 0.666996 | 0.513334 0.923876 | |||
| Testis | 45 (−5.1 to 10.6) | 5.293333 | 3.571631 | 4.220297 6.36637 | 8.8007 | 1.25×10−13 |
| 43 (25.1 to 28.3) | 0.465116 | 0.433086 | 0.331832 0.598401 |
Note.—Italic P values indicate statistical significance. Degrees of freedom: 86.
a
Cold countries are termed these of the first 25% percentile of average annual temperature (AAT) and the warm ones those of the last 25% percentile of AAT distribution.