Table 2.
GUS in COLD and ALTITUDE Populations Were Statistically Tested for Containing HG or CAG.
| Population | HG/HGG | HG/GUS | RR | P value | CAG/HGG | CAG/GUS | RR | P value |
|---|---|---|---|---|---|---|---|---|
| COLD | ||||||||
| Native Americans | 3,800/20,479 | 3/17 | 0.77 | 1.00 | 1,377/20,479 | 7/17 | 6.12 | 6.7×10−5 |
| Inuit | 3,800/20,479 | 1/8 | 0.55 | 1.00 | 1,377/20,479 | 4/8 | 7.44 | 1.0×10−3 |
| Eskimos (Siberia) | 3,800/20,479 | 7/41 | 0.75 | 1.00 | 1,377/20,479 | 6/41 | 2.18 | 5.5×10−2 |
| All | 3,800/20,479 | 10/61 | 0.72 | 0.664 | 1,377/20,479 | 13/61 | 4.71 | 5.9×10−6 |
| ALTITUDE | ||||||||
| Amhara | 3,800/20,479 | 16/113 | 0.62 | 0.297 | 1,377/20,479 | 9/113 | 1.18 | 0.570 |
| Oromi | 3,800/20,479 | 7/45 | 0.68 | 0.704 | 1,377/20,479 | 7/45 | 2.31 | 3.0×10−2 |
| Andeans-Tibetans | 3,800/20,479 | 18/76 | 1.04 | 0.251 | 1,377/20,479 | 20/76 | 3.91 | 1.3×10−11 |
| All | 3,800/20,479 | 41/223 | 0.81 | 0.948 | 1,377/20,479 | 36/223 | 2.27 | 1.5×10−7 |
Note.—Results show significant enrichment of genes under selection with cancer associated genes but no with housekeeping genes (Fisher’s exact test was used for counts <10). HG, housekeeping genes; GUS, genes under selection; CAG, cancer-associated genes; HGG, human genome genes; RR, risk ratio.
Italic P values indicate statistical significance.