Table 3.
GUS in COLD and ALTITUDE Populations Were Statistically Tested for Containing ONC or TSG.
| Population | ONC/HGG | ONC/GUS | RR | P value | TSG/HGG | TSG/GUS | RR | P value |
|---|---|---|---|---|---|---|---|---|
| COLD | ||||||||
| Native Americans | 724/20,479 | 1/17 | 1.63 | 0.458 | 1,038/20,479 | 4/17 | 3.95 | 9.0×10−3 |
| Inuit | 724/20,479 | 0/8 | 1.62 | 1.00 | 1,038/20,479 | 0/8 | 1.15 | 1.00 |
| Eskimos (Siberia) | 724/20,479 | 0/41 | 0.35 | 1.00 | 1,038/20,479 | 4/41 | 1.84 | 0.153 |
| All | 724/20,479 | 1/61 | 0.47 | 0.726 | 1,038/20,479 | 8/61 | 2.40 | 1.2×10−2 |
| ALTITUDE | ||||||||
| Amhara | 724/20,479 | 2/113 | 0.51 | 0.443 | 1,038/20,479 | 15/113 | 2.43 | 7.8×10−5 |
| Oromi | 724/20,479 | 0/45 | 0.32 | 1.00 | 1,038/20,479 | 2/45 | 0.88 | 1.00 |
| Andeans-Tibetans | 724/20,479 | 3/76 | 1.11 | 0.752 | 1,038/20,479 | 8/76 | 1.97 | 0.059 |
| All | 724/20,479 | 5/223 | 0.64 | 0.364 | 1,038/20,479 | 24/223 | 2.01 | 1.3×10−5 |
Note.—Results show preferential selection of tumor suppressor genes and not oncogenes (Fisher’s exact test was used for counts <10). ONC, oncogenes; GUS, genes under selection; TSG, tumor suppressor genes; HGG, human genome genes; RR, risk ratio.
Italic P values indicate statistical significance.