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Partial alignment of the SRCR domain of MARCO highlighting a residue undergoing positive selection at position 452 (Yap et al. 2015). Aquatic (n = 2) and terrestrial (n = 15) mammals possess a conserved aspartic acid residue at position 452, nonhuman primates (n = 5) vary. Neanderthals (n = 1), Denisovans (n = 1), and humans (n = 1) possess a glutamine residue. For a list of species included in each group, see table 2.
