Table 3.
Creatinine clearance, mL/min |
Dose of Colistimethate for Css,avg of 2 mg/La | |
---|---|---|
CBA, mg/d | Million IU/d | |
0 | 130 | 3.95 |
5 to <10 | 145 | 4.40 |
10 to <20 | 160 | 4.85 |
20 to <30 | 175 | 5.30 |
30 to <40 | 195 | 5.90 |
40 to <50 | 220 | 6.65 |
50 to <60 | 245 | 7.40 |
60 to <70 | 275 | 8.35 |
70 to <80 | 300 | 9.00 |
80 to <90 | 340 | 10.3 |
≥90 | 360 | 10.9 |
Abbreviations: CBA, colistin base activity; Css,avg , average steady-state plasma concentrations of colistin.
aDaily doses were calculated using Equation 2 in Table 2 and the midpoint of the creatinine clearance bands in the first column in the present table. Daily dose administered in 2 divided doses 12 h apart.