Table 3.

“Look-up” Table of Daily Doses of Colistimethate for a Desired Target colistin C_ss,avg of 2 mg/L for Narrow Windows of Creatinine Clearance

Creatinine clearance, mL/min	Dose of Colistimethate for Css,avg of 2 mg/La
	CBA, mg/d	Million IU/d
0	130	3.95
5 to <10	145	4.40
10 to <20	160	4.85
20 to <30	175	5.30
30 to <40	195	5.90
40 to <50	220	6.65
50 to <60	245	7.40
60 to <70	275	8.35
70 to <80	300	9.00
80 to <90	340	10.3
≥90	360	10.9

Abbreviations: CBA, colistin base activity; C_ss,avg , average steady-state plasma concentrations of colistin.

^aDaily doses were calculated using Equation 2 in Table 2 and the midpoint of the creatinine clearance bands in the first column in the present table. Daily dose administered in 2 divided doses 12 h apart.