Table 2.
National Incidence of Cryptococcal Meningitis in Botswana, 2013–2014
| Strata | Category | No. of Cases | Person-years | Incidence (per 100000 PYO) | 95% CI (per 100000 PYO) |
|---|---|---|---|---|---|
| Overall incidence | |||||
| All | … | 755 | 4231095 | 17.8 | 16.6–19.2 |
| Sex | Male | 466 | 2115031 | 22.0 | 20.1–24.1 |
| Female | 289 | 2116063 | 13.7 | 12.1–15.3 | |
| Age, y | 0–4 | 10 | 475589 | 2.1 | 1.0–3.9 |
| 5–9 | 4 | 467021 | 0.9 | 0.2–2.2 | |
| 10–14 | 5 | 458710 | 1.1 | 0.4–2.5 | |
| 15–19 | 20 | 457334 | 4.4 | 2.7–6.8 | |
| 20–24 | 37 | 450494 | 8.2 | 5.8–11.3 | |
| 25–29 | 79 | 424031 | 18.6 | 14.8–23.2 | |
| 30–34 | 156 | 371214 | 42.0 | 35.7–49.2 | |
| 35–39 | 138 | 295495 | 46.7 | 39.2–55.2 | |
| 40–44 | 141 | 212707 | 66.3 | 55.8–78.2 | |
| 45–49 | 76 | 158636 | 47.9 | 37.8–60.0 | |
| 50–54 | 40 | 125781 | 31.8 | 22.7–43.3 | |
| 55–59 | 27 | 107792 | 25.1 | 16.5–36.4 | |
| 60–64 | 10 | 83350 | 12.0 | 5.8–22.1 | |
| 65–69 | 4 | 55035 | 7.3 | 2.0–18.6 | |
| 70–74 | 3 | 42068 | 7.1 | 1.5–20.8 | |
| ≥75 | 3 | 45839 | 6.5 | 1.4–19.1 | |
| HIV infected (any CD4 T-cell count) | |||||
| All | … | 755 | 779997 | 96.8 | 90.0–104.0 |
| Sex | Male | 466 | 344120 | 135.4 | 123.4–148.3 |
| Female | 289 | 435877 | 66.3 | 58.9–74.4 | |
| CD4 T-cell count <200 cells/µLa | |||||
| All | … | 690 | 241445 | 285.8 | 264.9–307.9 |
| Sex | Male | 432 | 119120 | 362.7 | 329.3–398.5 |
| Female | 259 | 122325 | 211.7 | 186.7–239.2 | |
| CD4 T-cell count <100 cells/µLa | |||||
| All | … | 590 | 74845 | 788.3 | 726.0–854.6 |
| Sex | Male | 370 | 39304 | 941.4 | 847.9–1042.4 |
| Female | 221 | 35541 | 621.8 | 542.5–709.4 | |
| CD4 T-cell count <50 cells/µLa | |||||
| All | … | 415 | 22376 | 1854.7 | 1680.5–2042.0 |
| Sex | Male | 260 | 11846 | 2194.8 | 1936.1–2478.5 |
| Female | 156 | 10530 | 1481.5 | 1258.1–1733.1 | |
Abbreviations: CI, confidence interval; HIV, human immunodeficiency virus; PYO, person-years of observation.
aRestricted to individuals aged ≥15 years.