Table 1.
Variable | HTN (n = 9547) |
No HTN (n = 58858) |
DM (n = 5881) |
No DM (n = 80908) |
CKD (n = 1785) |
No CKD (n = 50626) |
||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
PY = 41291 | PY = 323788 | PY = 23918 | PY = 452258 | PY = 10053 | PY = 288382 | |||||||
Age, y | ||||||||||||
<40 | 2734 | 29 | 27002 | 46 | 1488 | 25 | 33831 | 42 | 430 | 24 | 24012 | 47 |
40–49 | 4201 | 44 | 21555 | 37 | 2530 | 43 | 30270 | 37 | 782 | 44 | 18553 | 37 |
50–59 | 2234 | 23 | 8673 | 15 | 1601 | 27 | 13789 | 17 | 480 | 27 | 7044 | 14 |
60–69 | 378 | 4 | 1628 | 3 | 262 | 4 | 3018 | 4 | 93 | 5 | 1017 | 2 |
Sex | ||||||||||||
Male | 8464 | 89 | 48908 | 83 | 4842 | 82 | 67621 | 84 | 1481 | 83 | 42200 | 83 |
Race | ||||||||||||
Non-black | 4836 | 51 | 35330 | 60 | 2893 | 49 | 47838 | 59 | 884 | 50 | 28592 | 56 |
Black | 4711 | 49 | 23528 | 40 | 2988 | 51 | 33070 | 41 | 901 | 50 | 22034 | 44 |
Injection drug use as HIV transmission risk | ||||||||||||
No | 6829 | 72 | 47617 | 81 | 4230 | 72 | 63921 | 79 | 1191 | 67 | 39948 | 79 |
Smokinga | ||||||||||||
Never | 717 | 8 | 5927 | 10 | 397 | 7 | 9153 | 11 | 146 | 8 | 5653 | 11 |
Ever | 2615 | 27 | 20798 | 35 | 1565 | 27 | 30142 | 37 | 646 | 36 | 19692 | 39 |
Missing | 6215 | 65 | 32133 | 55 | 3919 | 67 | 41613 | 51 | 993 | 56 | 25281 | 50 |
BMI, kg/m2 | ||||||||||||
<18.5 | 913 | 10 | 10268 | 17 | 429 | 7 | 14001 | 17 | 28 | 2 | 727 | 1 |
18.5–24.9 | 685 | 7 | 5961 | 10 | 408 | 7 | 8688 | 11 | 284 | 16 | 9293 | 18 |
25–29.9 | 334 | 3 | 2184 | 4 | 353 | 6 | 3401 | 4 | 150 | 8 | 5655 | 11 |
30–40 | 58 | 1 | 304 | 1 | 73 | 1 | 473 | 1 | 55 | 3 | 2391 | 5 |
>40 | 57 | 1 | 851 | 1 | 35 | 1 | 1102 | 1 | 12 | 1 | 401 | 1 |
Missing | 7500 | 79 | 39290 | 67 | 4583 | 78 | 53243 | 66 | 1256 | 70 | 32159 | 64 |
AIDS | ||||||||||||
No | 7811 | 82 | 47252 | 80 | 4668 | 79 | 65016 | 80 | 1341 | 75 | 40770 | 81 |
Calendar period of ART initiation | ||||||||||||
1996–1999 | 4651 | 49 | 17707 | 30 | 2804 | 48 | 25534 | 32 | 851 | 48 | 14895 | 29 |
2000–2005 | 3669 | 38 | 21231 | 36 | 2361 | 40 | 29892 | 37 | 766 | 43 | 19204 | 38 |
2006–2013 | 1101 | 12 | 17595 | 30 | 638 | 11 | 22624 | 28 | 138 | 8 | 14962 | 30 |
CD4 count, cells/µL | ||||||||||||
>500 | 1684 | 18 | 10208 | 17 | 1257 | 21 | 14474 | 18 | 284 | 16 | 9345 | 18 |
350–499 | 1219 | 13 | 8223 | 14 | 852 | 14 | 11790 | 15 | 197 | 11 | 7701 | 15 |
200–349 | 1772 | 19 | 11964 | 20 | 1021 | 17 | 17167 | 21 | 351 | 20 | 11118 | 22 |
<200 | 4870 | 51 | 28458 | 48 | 2751 | 47 | 37471 | 46 | 953 | 53 | 22459 | 44 |
ART and HIV RNA, copies/mL | ||||||||||||
≤400, on ART | 2848 | 30 | 16091 | 27 | 1933 | 33 | 23031 | 28 | 439 | 25 | 14279 | 28 |
>400, on ART | 3620 | 38 | 26026 | 44 | 2202 | 37 | 35650 | 44 | 853 | 48 | 24334 | 48 |
Off ART | 207 | 2 | 1235 | 2 | 187 | 3 | 1936 | 2 | 60 | 3 | 1120 | 2 |
Missing | 2872 | 30 | 15506 | 26 | 1559 | 27 | 20291 | 25 | 433 | 24 | 10893 | 22 |
Data are presented as No. (%) unless otherwise indicated. Statistical differences were assessed comparing cases to noncases for each NCD. All covariates were statistically significant (P < .05) with the exception of sex and BMI for the CKD analysis.
Abbreviations: ART, antiretroviral therapy; BMI, body mass index; CKD, chronic kidney disease; DM, diabetes mellitus; HIV, human immunodeficiency virus; HTN, hypertension; NCD, noncommunicable diseases; PY, person-years.
Smoking data in NA-ACCORD included observed and imputed observations. Across all 3 study populations, 3% of participants were imputed to be never smokers, 10% were imputed to be ever smokers, 7%–8% were observed as never smokers, 24%–29% were observed as ever smokers, and 50%–56% had missing smoking data. Results of our analyses pooled smoking coefficients across 5 datasets with imputed smoking status, and we obtained valid inferences by accounting for associated covariance matrices between imputed datasets.