Table 1.
Group | Dose | Frequency | Descriptiona |
---|---|---|---|
1, Standard | 150 µg/kg | Annual | 3 × 150 µg/kg annually for 3 years |
2, High dose | 400–800 µg/kg | Annual | 1 × 400 µg/kg and then 2 × 800 µg/kg for 2 years |
3, High frequency | 150 µg/kg | 3-monthly | 12 × 150 µg/kg 3-monthly for 3 years |
4, High dose, high frequency | 400–800 µg/kg | 3-monthly | 2 × 400 µg/kg and then 10 × 800 µg/kg for 2.5 years |
aAll individuals were additionally treated with a clearing dose of 150 µg/kg 3 months prior to the start of the study (immediately after the baseline nodulectomy) and with a final dose of 150 µg/kg 6 months after the final treatment.